The growing incidence of cancer poses a diagnostic and therapeutic challenge for modern medicine. Surgical treatment remains the standard of care in gynecology, particularly in cancer patients. Proper selection of surgical technique is of key importance for optimal therapeutic outcomes with the lowest risk of postoperative complications. Thorough knowledge of these complications will enable not only proper treatment, but also providing patients with complete, reliable information on possible complications, pain or distant consequences of the chosen procedure. Age and comorbidities are well-known primary factors modifying the postoperative risk. The paper discusses prevention and interdisciplinary treatment of the most important and most common complications after major gynecologic surgeries. Due to the common location of the gastrointestinal, urinary and genital tracts in the abdominal cavity, the treatment of complications after extensive gynecologic surgeries often requires cooperation with a surgeon and an urologist. Proper pre-anesthetic assessment, hydration of the patient, assessment of preoperative nutritional status and an early onset of postoperative nutrition may reduce complications resulting from the clinical condition of the patient. It should be also noted that the proportions of different procedures have changed in recent years, with a gradual replacement of conventional laparotomies and transvaginal surgeries with increasingly popular endoscopic techniques. The paper discusses the most important postoperative complications, their symptoms and treatment strategies based on a literature review.