Electrochemotherapy is a local therapy method reserved for cases not subject to surgery in advanced surface-localized cancers in the integuments. It may be applied in treating primary skin neoplasms (cancer and melanoma) as well as metastases of other neoplasms to the skin/hypodermis not qualified for another therapy (e.g. local removal or isolated limb perfusion, radiotherapy), regardless of the histological type of the neoplasm. It is a palliative type of treatment, and its objective is to obtain local control over cancerous lesions deteriorating the quality of life of the patients (infections, hemorrhages, limb function limitation). In selected cases, it is possible to obtain a long-term local control (e.g. in advanced, unresectable or qualifying to an extensive procedure on scalp and neck neoplasms and breast cancers with extensive dermis infiltration, reacting poorly to systemic treatment). Especially local breast cancer recurrence, frequently of large area or multiple with tissue infiltration, persisting despite systemic treatment, may be subject to electrochemotherapy. It especially applies to patients with disseminated cancer. In the paper, the authors are summarizing their experience in the application of that method among patients with breast cancer.