Intraoperative radiotherapy in the treatment of female genital malignancies
Affiliation and adress for correspondence

1 Katedra Onkologii i Klinika Brachyterapii, Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum w Bydgoszczy
2 Oddział Radioterapii I, Centrum Onkologii im. prof. Franciszka Łukaszczyka w Bydgoszczy
3 Oddział Kliniczny Ginekologii Onkologicznej, Centrum Onkologii im. prof. Franciszka Łukaszczyka w Bydgoszczy
4 Klinika Ginekologii Onkologicznej, Centrum Onkologii – Instytut im. Marii Skłodowskiej-Curie
Correspondence to: Dr n. med. Marta Biedka, Oddział Radioterapii I, Centrum Onkologii im. prof. Franciszka Łukaszczyka,
ul. I. Romanowskiej 2, 85-796 Bydgoszcz, tel.: 52 374 33 74, e-mail: martabiedka@tlen.pl
Acknowledgements
We are grateful to professor Łukasz Wicherek for his opinions and valuable comments. Particular thanks are due to Zbigniew Pawłowicz M.D.,
Director of Professor F. Łukaszczyk Cancer Center in Bydgoszcz.
Source of financing: Department own sources

CURR. GYNECOL. ONCOL. 2012, 10 (3), p. 215-225
ABSTRACT

Intraoperative radiotherapy is an innovative boosting technique enabling administration of single high dose of radiation, usually combined with external beam radiotherapy following surgery, used in the treatment of both primary and recurrent lesions. Such an approach offers several radiobiological, physical and clinical benefits. One of them is the option to irradiate selected anatomical areas identified during surgery as high-risk and/or residual tumor sites while protecting adjacent normal tissues, major nerve trunks and blood vessels, which may be displaced out of the irradiated field or covered with special shields. Key benefits of intraoperative radiotherapy include delivery of high total dose of radiation, superior local control and greater influence on overall survival. Available techniques of intraoperative radiotherapy include brachytherapy, generating high energy photon radiation using temporary or permanent applicators and mobile linear accelerators, which are the main source of electrons. Compared with conventional brachytherapy or teleradiotherapy, intraoperative radiotherapy offers several benefits including: ability to irradiate resection margins in order to reduce the risk of recurrence from tumor cells remaining the resection plane and reduction of risk of “geographical error”, enabling real-time inspection or palpation of surgical site. Furthermore, intraoperative radiotherapy makes possible reduction of radiation dose delivered to the skin, subcutaneous tissue and bones, while a large single dose provides an enhanced biological effect as compared with conventional radiotherapy. The aim of this paper was to point out types of female genital tumors which may be treated using intraoperative radiotherapy.

Keywords: intraoperative radiotherapy, surgery, gynecologic cancer, combined treatment, brachytherapy