The greater vestibular gland was first described by Danish anatomist Bartholin in 1675. Cancer of this organ was first reported 190 years later by J.M. Klob. To date, there are about 300 cases of squamous cell carcinoma of Bartholin’s gland reported in the literature. These conditions constitute about 0.03% of all female genital malignancies. During 28 years of activity of the Center of Oncology in Warsaw, Poland, 3 patients with primary squamous cell carcinoma of Bartholin’s gland have been treated. Prior to admission, they were observed at their place of residence and received antiinflammatory treatment. The lesions did not respond to this treatment but did not cause pain either. The patients suffered only moderate discomfort in this area. On admission, tumors measuring 4 cm and over were noticed, deeply infiltrating adjacent tissues without ulceration of overlying skin. One patient had a coexisting rectovaginal fistula. All patients underwent surgical treatment only. Radical vulvectomy with bilateral inguinal and pelvic lymphadenectomy was performed in 2 patients. One patient underwent local vulvectomy without lymphadenectomy due to internal-medical comorbidities and lack of consent to radiotherapy. She survived 30 months with dramatic recurrence of disease taking place during the final 6 months. One patient survived 11 years after undergoing 3 repeated excisions of recurrent tumors. One patient died 3 years after primary surgery due to cardiovascular events.