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Analysis of serum bFGF concentration in women with malignant and benign ovarian tumors

Rafał Moszyński1, Dariusz Szpurek1, Sławomir Michalak2, Sebastian Szubert1, Joanna Krygowska1, Stefan Sajdak1

Affiliacja i adres do korespondencji
CURR. GYNECOL. ONCOL. 2009, 7 (3), p. 199-205
Streszczenie

Aim of paper: The purpose of this paper was to assess serum bFGF level on women with malignant and benign ovarian cancer. Material and methods: The study encompassed 62 patients treated at the Department of Surgical Gynaecology of the Medical University in Poznań since 2006 thru 2009. The patients were subdivided into two groups: those harboring ovarian cancer (group 1; n=17) and those affected with a benign tumor (group 2; n=45). Serum bFGF level was assessed in both groups in relation to several features of the disease. Results: Median serum bFGF level in group 1 was 40.10 pg/ml (95% CI: 29.17-113.89), while in group 2 – 20.60 pg/ml (95% CI: 16.33-36.59). The difference was close to statistical significance (p=0.068). Prognostic value of bFGF in ovarian cancer in terms of sensitivity and specificity was 47% and 93%, respectively. Its positive predictive value (PPV) was 73%, negative predictive value (NPV) – 82%, and AU-ROC (area under curve) – 0.647. Analysis of AU-ROC for bFGF and CA-125 revealed superior predictive value of the latter in ovarian cancer (p=0.011). Median serum bFGF level in women with ovarian cancer at FIGO stage III and IV was 99.60 pg/ml (95% CI: 37.59-185.04) and was significantly higher than at FIGO stage I and II (16.29 pg/ml; 95% CI: 4.57-37.78; p=0,025). In clear-cell- and non-differentiated cancers, higher serum bFGF level was noticed (p=0.0037). No correlations have been noticed between bFGF and histological malignancy grade (p=0.56) or tumor size (group 1: p=0.56; group 2: p=0.87). Conclusions: In women affected with ovarian cancer, serum bFGF level is higher than in those harboring benign tumors and the difference is close to statistical significance. In women with ovarian cancer, serum bFGF level is significantly higher in those at more advanced clinical stage of the disease. BFGF may be a valuable adjunct in preoperative diagnostic work-up of ovarian tumors.

Słowa kluczowe
bFGF, CA-125, ovarian cancer, ovarian tumor, diagnosis