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Significance of D-dimers in first-line chemotherapy of ovarian cancer

Joanna Stanisławiak, Janina Markowska, Radosław Mądry

Affiliacja i adres do korespondencji
GIN ONKOL 2009, 7 (2), p. 114-122
Streszczenie

Background: Ovarian cancer is usually diagnosed late and is one of leading causes of genital malignancies-related mortality in women. Thromboembolic events are a frequent complication of neoplastic disease, occurring four-fold more often in patients with this disease and six-fold more often in persons undergoing chemotherapy. The aim of paper was to answer the following questions: What is the impact of first-line chemotherapy on D-dimer level during treatment? Is there any correlation between D-dimer level and FIGO stage of ovarian cancer? Is there a correlation between D-dimer level during chemotherapy and completeness of tumour resection? Is there a correlation between D-dimer level and incidence of thromboembolic complications during chemotherapy of ovarian cancer? Material and method: Study population initially consisted of 20 women with ovarian cancer treated at the Department of Oncologic Gynaecology of the K. Marcinkowski Medical University in Poznaƒ. Each patient underwent cytoreductive surgery with subsequent paclitaxel-plati-num chemotherapy. Peripheral blood has been obtained four times from each patient in order to assess D-dimer level, CA 125 tumour marker and blood count. Results: In persons with ovarian cancer, preoperative D-dimer level several-fold exceeded normal range. Application of chemotherapy significantly (p<0.05) reduced D-dimer level in women with ovarian cancer. Conclusions: Assessment of risk of thromboembolic complications in women with ovarian cancer during chemotherapy based on D-dimer level is not possible.

Słowa kluczowe
ovarian cancer, neoplasm, thromboembolic complications, D-dimers, first-line chemotherapy