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A 500 kHz hyperthermia assisted interstitial HDR brachytherapy in recurrent cervical and endometrial cancer treatment in previously irradiated field

N. Piotrkowicz1, J. Zieliński2, J. Jońska2, P. Dębicki3

Affiliacja i adres do korespondencji
GIN ONKOL, 2004, 2 (4), p. 232-236
Streszczenie

Introduction: The biological effectiveness of elevated temperature (hyperthermia) on the cancer cells is a well known issue. Nevertheless it is still not widely used in clinical practice, due to the technical difficulties. The main limiting factor is healthy tissue protection during the hyperthermia procedure. Hyperthermia, used as adjuvant treatment to brachytherapy, provides the possibility of lowering total radiation dose, without reduction its biological effect. Material: Hyperthermia procedures were performed in 8 endometrial cancer and cervical cancer patients with early recurrent local disease in previously irradiated area. Method: One to two interstitial hyperthermia procedures was performed, using rigid, metal needles, both for brachytherapy and temperature elevation. The total radiation dose was 30 Gy, delivered in 3 or 6 Gy per fraction. In case of 3 Gy per fraction, the two fractions per day, separated by at least 8 hours, scheme was used. The total treatment time ranged between 5 and 14 days. Hyperthermia was performed concurrently with brachytherapy. Results: During the treatment, no acute reactions were observed. In each case, the tumor regression over 50% was noted. During the 3 to 14 months follow-up period, the complete vaginal tumor regression was seen in 6 of 8 cases.

Słowa kluczowe
cervical cancer, endometrial cancer, hyperthermia, brachytherapy