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The role of free radicals in the pathophysiology of carcinogenesis – a current overview

Beata Maćkowiak-Matejczyk, Marcin Jóźwik, Maciej Jóźwik

Affiliacja i adres do korespondencji
GIN ONKOL, 2004, 2 (2), p. 71-85
Streszczenie

Carcinogenesis, or formation of malignant neoplasms, is a complex process which includes the phases of transformation, promotion and progression. Reactive oxygen species (superoxide radical anion, hydroxyl radical, and hydrogen peroxide) may be generated during all stages of both mutagenesis and carcinogenesis, and consequently contribute to the impairment of cellular genetic material. This paper is a review on current concepts and understanding of the role of free radical involvement into the mechanisms of formation and spread of neoplastic disease.

Słowa kluczowe
carcinogenesis, hydrogen peroxide, hydroxyl radical, superoxide radical anion, xenobiotics